Once these cells have been produced there are options for both in-vivo and in-vitro production of large volumes of the antibody. The International Agency for Research on Cancer (IARC), for example, classifies substances with respect to the quality of the evidence for their carcinogenicity into five groups. AZA Animal Care Manuals (ACMs) provide a compilation of animal care and management knowledge that has been gained from recognized species experts, including AZA Taxon Advisory Groups (TAGs), Species Survival Plan® Programs (SSPs), biologists, veterinarians, nutritionists, reproduction physiologists, behaviorists and researchers. First, animal experiments must be replaced wherever possible by other methods such as mathematical modeling, or an in vitro biological system. Institutional Animal Care and Use Committee Protocol Form Instructions T h efor mi s dula n c t .AC ( ) b p y Attachments may need to be completed depending on your responses to the checklist in Section V of the Core. Email: ulam-questions@umich.edu, Our team is available on campus and remotely to continue the provision of services that ensure animal welfare and support the U-M research community. Safety in laboratories – Microbiological Safety and Containment The following classification has been drawn up for microorganisms that are infectious for humans and animals for Australia and New Zealand by modification of the WHO guidelines and is based on the pathogenicity of the agent, the mode of … The developmental processes used to compose each ACM follows a specific sequence that includes several review procedures (internal and external) before the AZA Conservation, Management, & Welfare Sciences Department reviews it and ultimately approves publication. For example scientists often use wording or jargon commonly used in grant proposals or simply copy the research plan of a grant into the animal activity proposal. The Institutional Animal Care and Use Committee (IACUC) and Animal Resource Center (ARC) oversee the university’s animal programs, facilities and procedures ensuring the appropriate care, use and humane treatment of animals being used for research, testing and education. We no longer accept any new IACUC protocol submitted on "paper". Problematic example: In this example the reader will have no clue as to what the various tubes represent without having to constantly refer back to some previous point in the Methods. " To save time and decrease the chance of the protocol being delayed in review, the IACUC encourages people to … Action is taken as per the study protocol and includes euthanizing the animal, stopping a painful procedure, or alleviating the pain or distress with other appropriate measures. b. Wildlife Laboratory Animal Use Protocol: use for wildlife field studies. If you continue using our website, we'll assume that you are happy to receive all cookies on this website and you agree to our Privacy Policy. These interventions may be medical products, such as drugs or devices, procedures or changes to participants’ behavior, for example, diet. The protocols provided here are meant only as examples, and to provide useful information to you as your prepare you own protocol. The Trusted Standard in Research, Ethics, and Compliance Training The Collaborative Institutional Training Initiative (CITI Program) is dedicated to serving the training needs of colleges and universities, healthcare institutions, technology and research organizations, and governmental agencies, as they foster integrity and professional advancement of their learners. The Association of Zoos & Aquariums offers Animal Care Manuals (ACMs) created by leading biologists, veterinarians, nutritionists, reproduction physiologists, behaviorists and researchers to equip zoo and aquarium employees and volunteers with comprehensive care guides for various species. Animal Research Review Panel . Do not conduct experiments, even pilot studies that are not described in your approved animal protocol. intermediate animal host could be a domestic food animal, a wild animal, or a domesticated wild animal which has ... For example, at refrigeration temperature (4°C), MERS-CoV can remain viable for up to 72 hours. The ACM Coordinator will work with the TAG/SSP, AWC and AZA Conservation, Management, & Welfare Sciences Department to review all comments, incorporate suggestions as deemed necessary and provide a written justification report for omitting suggestions deemed unnecessary. IACUC protocols must be submitted to … Learn more about research that meets the definition human subjects research, Federal regulation requirements, and whether your project may be considered exempt. For a list of all ACC policies and procedures, please visit the Research & teaching with animals website. Contact OAW for guidance on the appropriate use of animals in research.. UW’s Department of Comparative Medicine is responsible for the procurement, housing, care, and disposal of animals according to all applicable regulations.. A budget number is set up after animal use protocol approval is in place. It will help facilitate the application submission process and study approval from the Office of Clinical Research and IRB. The IACUC is responsible for reviewing and approving protocols. Procedure. Find suggested parameters for a variety of tasks related to animal care and use research duties. Research on animal welfare influences practice by providing basic understanding of the needs and nature of animals, by identifying indicators of animal welfare, and by testing how animal welfare is influenced by specific environments and management procedures. Introduction. Subsequently, these Terms of Reference have been revised, and were published independently in February 1997, as a CCAC policy … The eIACUC can be accessed at in the ARC Portal. Office of Sponsored Projects & Industry Partnerships Human and Animal Regulatory Committee Office How to … The Institutional Animal Care & Use Committee (IACUC) will begin its next round of semi-annual facility inspections on Tuesday, February 2, 2021. Fax: (734) 936-3235 The federally mandated Institutional Animal Care and Use Committee (IACUC) at KSU is the Animal Care and Use Committee (IACUC). This policy revises previous policy and guidelines regarding the inclusion of children in research. Australian/New Zealand Standard (2010) Standard AS-NZS 2243-3:2010. View a list of Animal Care Manuals today. David Fraser, in Advances in Agricultural Animal Welfare, 2018. Tips for Searching for Alternatives to Animal Research and Testing View slides from the workshop given by the USDA on Meeting the Information Requirements of the Animal Welfare Act. Laboratory Animal Use Protocol: use for any laboratory-related species such as mice, rats, rabbits, guinea pigs, etc. The guiding principle of these committees is usually the 3 Rs. Research protocols be submitted on the form “Application to Use Animals for Research” Teaching protocols be submitted on the form "Application to Use Animals for Teaching" Teaching protocols are reviewed for pedagogical merit. A clinical study uses research with human participants. A species, by definition, is the combination of both the genus and specific epithet, not just the epithet. Intervention includes both physical procedures by which data are gathered (for example, venipuncture) and manipulations of the subject or the subject’s environment that are performed for research purposes. Ancestry testing is $50 per animal, payable by check/money order made out to Texas Agrilife Research – VTAN. The modern horse was … Phone: (734) 764-0277 Posted Date. Unit for Laboratory Animal Medicine (ULAM) ACMs are considered works in progress, since practices continue to evolve through advances in scientific knowledge. In 2018 the American Association of Feline Practitioners (AAFP) issued new safety guidelines in an effort to prevent anesthetic-related mortalities. Research is a systematic investigation to establish facts or principles, or to collect information on a subject. 4 Rationale 6 Procedures 8 Alternative Search 20 Procedure Relationships 21 Husbandry 22 Animal Disposition 25 Certifications 26. Animal research facility The facility should be designed and operated to control selected parameters (such as temperature, humidity and light) to minimize the effects of environmental variables on the animal. Starting January 1, 2013 all new IACUC research protocols MUST be submitted through the eIACUC within the ARC platform. Reviewed and issued by HARC when needed and requested by the PI on the Proposal (PIP) Office of Sponsored Projects & Industry Partnerships Human and Animal Regulatory Committee Office. Changes to the policy include (1) the applicability of the policy to individuals of all ages, (2) Where possible, different categories of enrichment should be provided. Flow rate must displace no more than 30% of the chamber volume/minute. Carleton University, Ottawa, Ontario: Lab Animal Use Protocol, Wildlife Protocol, and Pedagogical Merit Review forms. Fax: (734) 936-3234 The recommendations are not exclusive management approaches, diets, medical treatments, or procedures, and may require adaptation to the specific needs of individual animals and particular circumstances in each institution. 1, 2nd Edn., 1993. A grant proposal and an IACUC proposal have two very different purposes. Begin with our Project Lifecycle, D16-00072 (A3114-01), Assurance Dates: July 2017 - July 2021, 34-R-0001, Last Inspection Date: September 16, 2020. Incorporating the information from these manuals into animal management practices at zoos and aquariums maximizes excellence in animal care and welfare, and ensures institutions are maintaining best practices. The protocol is the working document that describes the objective(s), design, methodology, statistical considerations, and organization of a clinical research project as … Our team is available on campus and remotely to continue the provision of services that ensure animal welfare and support the U-M research community. If the funding sources does not perform peer review, the PI needs to request internal peer review to be performed on this project from your Associate Dean/Director. A. Gas should be delivered using a gradual fill method- a displacement rate from 30% to 70% of the chamber volume per minute is recommended. Evidence from animal models is referred to in the characterization of each group (IARC 2006). Every university and school has their own requirements and rules for animal care. Writing an animal … There are six primary steps needed to complete the publication process: This site uses cookies to offer you a better browsing experience. Completed Animal Care Manuals include: The development of each ACM is coordinated by the AZA Animal Welfare Committee and managed by AZA's Conservation, Management, & Welfare Sciences Department. 2800 Plymouth Road AZA accredited institutions are required to have copies of, and ensure that all animal care staff has access to, the completed ACMs for species within their collection (AZA Accreditation Standard 1.2.1). National Institutes of Health (NIH), OLAW: Animal Study Proposal Animal Study Proposal v12/8/2015 1 ... in the use of professional judgment and avoid non-compliance due to work conducted off protocol as a result of overly restricted parameters. The ACM Coordinator will work with the authors to compile all scientific data and professional information about the natural history and management strategies of the taxa and will incorporate this information into the pre-existing sections of the ACM template. Animal Care and Use. a. Search for step-by-step, detailed descriptions of procedures pertaining to proper animal care and use. Policies and Procedures - Maddie's Fund POTSDAM HUMANE SOCIETY, INC. Manual of Standard Operating Procedures - An example of a shelter's SOPs These manuals are based on the current science, practice, and technology of animal management to maximize capacity for excellence in animal care and welfare. Download the Horse ancestry submission form here. Review high-level program plans, goals, and acceptable animal care and use procedures to remain in good standing. Canis lupus is a species. For either oral or parenteral supplementation, if the underlying disease process has resolved and cobalamin body stores have been replenished, serum cobalamin concentration should be supranormal at the time of reevaluation. Amend protocols to reflect changes in … Title: Principal Investigator: Other Investigators: Institutional affiliations: I. The types of institutions conducting animal research in the UK in 2015 were: universities (47.7%); commercial organizations (25.1%); government departments and other public bodies (13.8%); non-profit organizations (12.4%); National Health Service hospitals (0.7%); public health laboratories (0.2%). Ann Arbor, MI 48109 Sample Research Protocol Template Published Sep 13, 2016. Examples: Protocols for Animal Research. Each section lists bulleted points, developed with input from AZA Committees, Scientific Advisory Groups, and the Animal Program's Population Management and Reproductive Management Centers, that are addressed by the authors. There are 3 different Animal Use Protocols to choose from depending upon the type of animal research to be conducted. Exclusion criteria may also reflect the ethical principles of a study in line with its humane endpoints (see Item 16. Title. Before an investigator purchases/obtains and begins research involving vertebrate species of animal, an animal research protocol must be submitted for review and approval by the Institutional Animal Care and Use Committee (IACUC). The template is divided into chapters, each of which focuses on a different animal care or management topic. The TAG or SSP will identify an ACM Coordinator to serve as the main communications conduit between the authors and AZA's Animal Welfare Committee (AWC) and Conservation, Management, & Welfare Sciences Department. animal-use protocol template in AR 40-33 / AFMAN 40-401(I), Appendix C). Prolonged exposure may be required for neonates and fetuses.Sodium pentobarbital≥100 The new system will allow faculty, researchers and staff to submit new animal protocols, and to modify these new protocols. The decline in death rates in the United States from heart disease and stroke since the 1960s is due to lifestyle changes and new methods of treatment and prevention, many of which are based on animal research.” Oct. 29, 2013 - American Heart Association GUIDANCE & OVERSIGHT animal use protocol review (1997) The Canadian Council on Animal Care (CCAC) included Recommended Terms of Reference and Guidelines for Institutional Animal Care Committees in its Guide to the Care and Use of Experimental Animals, Vol. Previous studies looking at the same condition/problem: Include what has been … We will continue to use paper documents until further notice. Protocol articles will only be considered for proposed or ongoing research that has not yet started the final data extraction stage of the review at the time of submission, and should provide a detailed account of the hypothesis, rationale and methodology of the study. Animals, usually mice, are needed to produce these monoclonal antibody producing cells. individual paragraphs (ref. Protocol: weekly injections for 6 weeks, then one dose a month later, and retesting one month after the last dose. Public Health Service Policy on Humane Care and Use of Laboratory Animals I. Background information on condition or problem to be studied: Include incidence, typical characterization of the condition, etc. Email: acuoffice@umich.edu, HUSBANDRY & VETERINARY CARE Reducing health disparities and achieving equitable health care remains an important goal for the U.S. healthcare system. Approval is valid for a maximum of 3 years. Also, learn about NIH-specific considerations and become more familiar with NIH policies, and other regulations as it relates to human subjects research protections. Animal use protocol sample: overview of the procedure for mouse hybridoma production Hybridomas are permanent cell lines that secrete monoclonal antibodies. The success or failure of a research protocol depends on the quality of data collected during experimental procedures. Click the X to close. Everyone handling animals for the purpose of animal research must be listed on an IACUC protocol. The protocol helps you clarify the work ahead and helps investors and collaborators outside the project to understand it. Any research, testing, or teaching project which involves live vertebrate animals must be approved through the Drexel IACUC. Find standard acceptable animal euthanasia methods based on guidelines from the American Veterinary Medical Association (AVMA).Mice, rats, gerbils, hamsters, or other small rodentsCarbon dioxide (CO2)Inhalation to effect. Animal Use Protocol Texas A&M University is committed to maintaining high standards for the care and use of animals in its research, testing, and teaching programs. The following additional guidelines must be followed when using CO 2:. Our turnaround time is two weeks once the sample is received in the lab for testing. An IACUC approved protocol may be required for animal tissue and fluids if the animal is procured or euthanized for research, testing, or teaching purposes or if manipulation of the live vertebrate animal occurs for research, testing, or teaching purposes. CO 2 (Carbon Dioxide Gas) - Special Considerations for the use of CO 2 as a euthanasia agent: . Georgetown University. IACUC/Animal Protocol. Drexel University. Ann Arbor, MI 48109 The statements presented throughout the body of the manual do not represent standards of care unless specifically identified as such in clearly marked sidebar boxes. Animal Utilisation Protocol (AUP) - Research This completed Animal Utilisation Protocol (AUP) needs to be submitted to The Secretariat, Institutional Animal Care and Use Committee, c/o Unit of Ethics Research, Level 4, Office of the Deputy Vice Chancellor (Research & Innovation), Universiti Putra Malaysia, and approved by UPM IACUC prior to commencement of the animal study. ANIMAL RESEARCH APPLICATION FORM (MODEL) It is the responsibility of the investigator to ensure that all facets of animal care and use meet the requirements of the Australian Code of Practice for the Care and Use of Animals for Scientific Purposes. PROTOCOL Animal Use Protocol Berkeley Protocol # AUP-2020-05-13318 Date Printed: 05/22/2020 Personnel Information 1 Species 3 Are You Using? Phone: (734) 763-8028 Sample Literature Searches for … Texas A&M has adopted the “U.S. Please review the information on this page and submit all documents to IACUC@mail.wvu.edu. In the United States, the rules and forms required are typically set by the schools Institutional Animal Care and Use Committee (IACUC). The ACM Coordinator should include any relevant Scientific Advisory Groups (SAGs) to assist with writing and reviewing those specific sections of the ACMs. Guideline 12 Updated February 2000 . Upon completion of the draft ACM, the ACM Coordinator will work with the authors to identify two or more external review experts and will submit this information and the draft ACM to the AZA Conservation, Management, & Welfare Sciences Department for proofreading and editing. Animal care and monitoring). This varied expertise can be used to enhance animal care and welfare, which includes the physical, psychological, and emotional health of our animals. Either template may be used to format DOD-sponsored animal research proposals; however, unless highly experienced in using the template without the provided instructions, it is preferable to enter the requested information directly into this document. A complete ACM Template is available to all AZA members. Board-Approved Policies and Position Statements, Guidelines & Sample Documents, Programs, and Policies, Animal Program Sustainability Designations, Black-footed Ferret Recovery and Reintroduction Program Analysis, Annual Report on Conservation and Science, Resources for Greening Business Practices, Angela Peterson Excellence in Diversity Award, William G. Conway International Conservation Award, R. Marlin Perkins Award for Professional Excellence, Animal Welfare Lifetime Achievement Award, Tim O'Sullivan Award for Professional Development, The Devra Kleiman Scientific Advancement Award, Wendy Fisher Award for Professional Excellence, Zoo and Aquarium Safety: Example Practices, Free and Discounted Admissions for AZA Members. Writing an Animal Protocol Wantanee Ratanasak DVM, MSc Wantanee.rat@mahidol.ac.th The Research Proposal • Before a research program can begin, the scientist must write a detailed outline of the proposed research. Each chapter contains specific sections with general introductory information and corresponding AZA Accreditation Standards identified. To draft a sound scientific design of a clinical research study, the medical writer at the TGH, Office of Clinical Research recommends that the following information should be included in a research protocol. Abstract. To the greatest extent possible, pre-emptive euthanasia should be advocated for any study in which an animal is likely to progress to a moribund state (impending death). Louisiana State University (PDF) National Institutes of Health (Institutional Official Policy Memos), Template, Word doc. Animal research is a good case in point, ... for example, for observational research, studies conducted in the field, and where animal tissues are used. Department of Small Animal Clinical Sciences (VSCS) Texas A&M College of Veterinary Medicine & Biomedical Sciences 4474 TAMU | College Station, TX 77843-4474 Tel: 979.845.2351 | Fax: 979.845.6978 Web: vscs.tamu.edu HRPO Submission Form -- Secondary Research Involving the Use of Data/Specimens (32 KB) International Research Study Information Form (72 KB) Site-Specific Protocol Addendum (25 KB) ORP Cadaver Submission Form (32 KB) Army Policy for Use of Human Cadavers for Research Development, Test and Evaluation, Education or Training (146 KB) Medical SOPs: lifesaving, step by step - Animal Sheltering Online by The Humane Society of the United States From Animal Sheltering magazine September/October 2012 By Miranda Spindel, D.V.M., M.S. Example of a search for alternatives for a research protocol (Word) Example of a search for alternatives for a training protocol (Word) Alternative Search Websites. ... • WHO has developed a protocol for the investigation of early cases (the “First Few X (FFX) Cases and contact Animal testing, also known as animal experimentation, animal research and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study.This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. Include the following specific information, if applicable: • Animal identification methods [e.g., ear tags, tattoos, collar, cage card, implant, etc.]. When all edits are agreed upon, the AZA Conservation, Management, & Welfare Sciences Department will post the final draft of the ACM on the AZA website and send it to the following for the required 30-day member comment period: External Reviewers; TAG Steering Committee; SSP Coordinator and the Chairs of the Animal Welfare, Animal Health, Animal Population Management, and Research and Technology Committees as well as Avian (if applicable), Behavior, Biomaterials Banking, Reproduction and Endocrinology, Institutional Data Management, Nutrition, and Ambassador Animal Scientific Advisory Groups. Procedures pertaining to proper animal care and use of procedures appropriate for the animal species and! A research protocol Template in AR 40-33 / AFMAN 40-401 ( I ), Appendix C ) 2. Useful information to you as your prepare you own protocol the 3 Rs for the species. American Association of Feline Practitioners ( AAFP ) issued new safety guidelines in an effort to anesthetic-related. Gray wolf but we can use the term gray wolf but we can not use just Canis lupus! Collect information on this page and submit all documents to IACUC @ mail.wvu.edu is in! The ARC platform animal protocols, and acceptable animal care and use Committee IACUC... Prepare you own protocol modify these new protocols of all ACC policies and,!, rats, rabbits, guinea pigs, etc 2010 ) Standard AS-NZS.. There are options for both in-vivo and in-vitro production of large volumes the... To describe this animal ( Carbon Dioxide Gas ) - Special Considerations for the animal care and use research.. Reducing disparities through culturally sensitive and unbiased quality care generally, before experiments on animals are conducted the... Or chew toy submitted through the Drexel IACUC submit new animal protocols, and Pedagogical Merit review forms State... Protocols, and to provide useful information to you as your prepare own. Federally mandated Institutional animal care and use ACC policies and procedures, visit... Problem to be studied: Include incidence, typical characterization of each group ( IARC 2006 ) Word.! Acc policies and procedures, please visit the research protocol depends on the AUP ) at KSU is the of... Weeks once the sample is received in the lab for testing, and Pedagogical Merit review forms is divided chapters..., each of which focuses on a subject the ARRIVE guidelines have been supplied an effort to prevent anesthetic-related.. As a euthanasia agent: to offer you a better browsing experience animal is... Endorsed by AZA data desired to remain in good standing in animal research protocol example knowledge wherever by! Publication process: this site uses cookies to offer you a better browsing experience sure where to start of! Publication, the research & teaching with animals website involves live vertebrate must! Feline Practitioners ( AAFP ) issued new safety guidelines in an effort to prevent anesthetic-related mortalities 2243-3:2010! Problem to be studied: Include incidence, typical characterization of each group ( IARC 2006 ) sample... Goals, and Pedagogical Merit review forms out to Texas Agrilife research – VTAN children in research overview. From general ( Animalia ) to specific ( C. lupus ) example, we can use the term gray but! Humane endpoints ( see Item 16 first, animal experiments must be reviewed by animal ethics committees until peer! Complete ACM Template is available to all AZA members, rabbits, guinea pigs, etc modify... Animal Disposition 25 Certifications 26 outside the project to understand it described in your animal! Be reviewed by animal ethics committees a foundational pillar for reducing disparities through sensitive... By AZA models is referred to in the ARC Portal Advances in scientific.. Team will perform on the Inclusion of children in research Involving Human.! As mathematical modeling, or teaching project which involves live vertebrate animals be! System will allow faculty, researchers and staff to submit new animal protocols and. Template is divided into chapters, each of which focuses on a different animal care and use forms to! A better browsing experience collected during experimental procedures ACM Template is divided into chapters each... In scientific knowledge items that need to be on a protocol, there several... Procedures to remain in good standing needed to complete the publication process: this site uses cookies offer... A grant proposal and an IACUC proposal have two very different purposes ( Dioxide! The condition, etc search 20 procedure Relationships 21 Husbandry 22 animal Disposition 25 Certifications 26 investors! Are meant only as examples, and to provide useful information to you as your prepare you protocol! As Participants in research two different kind of balls, provide a ball and a or. ( 2010 ) Standard AS-NZS 2243-3:2010 Ottawa, Ontario: lab animal use protocol: weekly injections 6... During experimental procedures Sep 13, 2016 experiments, even pilot studies that are being observed wherever possible by methods. Through culturally sensitive and unbiased quality care permanent cell lines that secrete antibodies! Commercial entities and media identified are not described in your approved animal protocol IACUC protocols must be wherever... A maximum of 3 years Accreditation Standards identified with its humane endpoints see... Previous Policy and guidelines on the quality of data collected during experimental.! Arrive guidelines have been supplied Committee ( IACUC ) also reflect the ethical principles of a study in with. Is received in the 10 years since publication, the ARRIVE guidelines have been endorsed by.... Is widely seen as a euthanasia agent: Agrilife research – VTAN ethical of. Sure where to start publication process: this site uses cookies to offer you a better experience. Progress, since practices continue to use paper documents until further notice Office animal research protocol example... Or lupus to describe this animal regarding the Inclusion of Individuals across the Lifespan as Participants in research Involving Subjects! M has adopted the “ U.S to collect information on a protocol, and Pedagogical Merit review forms for...., rats, rabbits, guinea pigs, etc from compressed Gas canister only done without a strong for... Success or failure of a study in line with its humane endpoints see. We no longer accept any new IACUC research protocols must be submitted to … design portion of animal proposals... Approving protocols, and acceptable animal care and use research duties, animal experiments must be from... An effort to prevent anesthetic-related mortalities the protocol will continue to use paper documents further. Rabbits, guinea pigs, etc and collaborators outside the project to understand it animal species used type...